Streptomycin resistance in tuberculosis

2020-01-27 13:05

It is estimated that in 80 per cent of patients with pulmonary tuberculosis treated with streptomycin for four months or longer, the tubercle bacilli acquire resistance to more than 10 mcg. of streptomycin per cc. of culture medium. 5 x 5 Barnwell, J. B. , Bunn, P. A. , and Walker, A. M.Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with missense mutations in the rpsL gene, which encodes ribosomal protein S12, or with base substitutions at position 904 in the 16S rRNA. streptomycin resistance in tuberculosis

Jul 01, 2011 Recently, the gidB gene was found to be associated with lowlevel streptomycin resistance in Mycobacterium tuberculosis. Mutations in gidB have been reported with high frequency, and this gene appears to be very polymorphic, with frameshift and point mutations occurring in and strains.

Feb 06, 2010 Streptomycin. Streptomycin is a firstline bactericidal agent with a minimum inhibitory concentration (MIC) against M. tuberculosis of 8 gmL. Streptomycin is usually given by intramuscular (IM) injection at a dose of 15 mgkg per day (up to 1 g per day) for the first 1 or 2 months of treatment. Oct 29, 2018  An aminoglycoside antibiotic derived from Streptomyces griseus that is used in the treatment of tuberculosis and sensitive Gramnegative infections. Streptomycin is not absorbed from the gastrointestinal tract but, after intramuscular administration, it diffuses readily into the extracellular component of most body tissues and it attains bactericidal concentrations, particularly in tuberculous streptomycin resistance in tuberculosis From the point of view of the community there is the risk that patients with unsuitable lesions ineffectively treated may disseminate organisms, so that an increasing number of new cases of all forms of tuberculosis may in future be found to be unresponsive to streptomycin.

One of the handicaps in streptomycin treatment of tuberculosis arises from the apparent rapidity with which tubercle bacilli acquire resistance to this drug. Patients under treatment with streptomycin may at times discharge tubercle bacilli several thousand fold more resistant to streptomycin streptomycin resistance in tuberculosis

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